Lol, you're using the opiod argument because you think it's a slam dunk.
People who use drugs are not harming anyone with force or fraud. And if drugs were decriminalized, they'd be far cheaper, and drug addicts wouldn't have to turn to crime to pay for their drugs. The drug war is a massive failure and a huge civil rights violation.
I would also hope that, when drugs are decriminalized, the drug addict would choose a safer opiate, like simple morphine or heroin. Yes, they are very addictive, and they can cause overdoses, but if people could buy their drugs in a legal market they could actually get good dosage information and it wouldn't be cut with shit like fentanil.