40+ applications?
How about picking the top 5 that you are the best culture fit for and most excited about. After that, create well written 100% custom cover letters and relevant resume. You will get a 100% response, this has worked for me in the past and is a win/win for you and the employer.
In the long run it takes about the same amount of time. Now wear the employers hat...which one are you more likely to read and then engage with?