Depends on the startup and their product.
If you are generally interested in the domain and want to get your hands dirty:
Being able to do 'Hello World`'s in the following techs:
* A simple contract on https://blockstream.com/2017/10/30/simplicity.html
* A simple contract on https://solidity.readthedocs.io/en/develop/
* A simple merchant app using one of the 3 implementations of http://lightning.network/
* A simple permissioned blochain on https://www.hyperledger.org/