When I moved to SF, I (fortunately) had a couch to crash on for a week. The city is eminently walkable. I spent the first few days just walking through neighborhoods and looking at whatever apartments on Craigslist I could schedule walkthroughs for. I walked the Mission from 26th and Potrero back and forth to 14th and Dolores, all of SOMA, up and down Hayes Valley and the Haight. I knew from doing a little research beforehand that the Marina and North Beach weren't my scene.
Once I found a neighborhood that felt comfortable, I narrowed my focus and drilled down on finding a place.
If you can do something similar, I highly recommend it.