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Define start up. Are you going to be profitable from day one? London, that's where the big money is. Do you need VC money? London, that's where the big money is.

Are you self financing and have limited run way? Go to cheaper places.

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I second this, if you think you can get to money within the first year get yourself to London. If you are within the UK and can't get to money within the first year, live within 1 hour commuting distance and plan to move there. This has worked pretty well for me. It is extremely expensive to be able to live here but the ability to casually attend and walk to serendipity tech networking events is a real luxury and I save a lot of money commuting. The lively eco system around the Techhub interested people is exciting and I recommend it.

I third this. I've avoided London for many years (traffic, overpopulation, cost) but now that I'm here I realise I should have done it earlier. It's almost like another country - everything is going on here.

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