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I don't know. When I drink more than 2 cups my sleep suffers and even my personality changes. I get pretty hyper and less patient. With my girlfriend I can tell immediately whether she has had coffee just from the way she talks.

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Try to cut off the caffeine consumption by 3pm and your sleep should not suffer (based on the half life of caffeine and average human adult body weight).

Disclaimer: I consume ~4 cups of coffee per day between 8am and 3pm and get ~8 hours of sleep per night.

The CYP1A2 gene affects how quickly you metabolize caffeine. Stopping at 3pm may not be enough.

I’ll check my CYP1A2 SNPs on 23andme in the AM and report back.

I'm not sure if that's sarcasm or not. Maybe I'm just not hip.

Not sarcasm at all. Last time I checked, 23andme reports if you’re a fast or slow caffeine metabolizer. I just don’t recall offhand which I am.

Why would that be informative? It doesn’t tell you your protein expression levels nor effective enzymatic activity.

You don't know what - if this general result could be invalidated by your personal experience not matching it?

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