Region locked - You have to have the US version of the game to play against US players and no playing against South Korea.
Removed 'spawn' install - locked down installation so you can play 1 copy on several computers - but only with each other.
The single player campaigns are going to be broken up into 3 $60 games.
There's the Real-id fiasco that they've backed off a little bit on.
User made maps aren't files that can be passed around, they MUST be hosted on bnet's servers, and there's a 25MB limit per-account.
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However you fall on the question, the real problem is we end up not talking about the various merits of the game and how much we can't wait to play it, but instead dissect the policies surrounding the game.
Also, what happens when battle.net is down?