"Some of the stuff in this sounds nice but I feel it lacks some honesty. "What is the thing you have been the most wrong about?" And you say that the worst error in judgment you've made is an off-hand remark in a meeting?"
Huh? That isn't how I read it at all.
From the article:
"Question: What about you yourself—what have you personally been most wrong about?
Answer: One thing is how fast things change.[Stuff about meeting here]You think you have this experience—and we talked about how important experience is for having intuitions—but experience can go out of date very quickly."
To me he seems to be saying that one of his major mistakes is underestimating how fast things change, and underestimating the erosion of the value of his experience in guiding his intuition (He just finished talking about the importance of intuition for situations where statistics and data can't help/don't exist.)
Given that he was speaking about a professional context [1] and the position he occupies at Google (Director of Research), where anticipating change would be presumably part of his job description, that sounded to me like admission of a major lapse, somewhat different from "My biggest mistake was an off hand remark I made at a meeting", as you seemed to imply.
He was using the meeting incident as a concrete example of a rather large failing. How is it "dishonest"?
[1] The whole interview is about errors in a professional context , about Google and his work there, so I wouldn't expect to hear about whether he got stoned as a teenager and got thrown in jail! ;-)