It's not craps gambling, it's like betting on a boxing match. The bookie odds are based on previous records and some valuation model, you only come out ahead in the long if you have a superior valuation model, insider knowledge, luck, etc.
http://www.cmegroup.com/bitcoin
However the largest electronic brokerage in the US considers it unwise:
https://cointelegraph.com/news/cme-clearing-member-to-regula...
https://www.interactivebrokers.com/download/11-IB17-1145-tp-... [PDF]
His doomsday scenario is based on the Bitcoin price rising rapidly.
The CME's volatility limits would kick in, preventing shorts buying to cover their positions. This leads to "ruin" for them and the CME, and contagion for the real economy.
He has a good point, since losses on short positions are theoretically infinite, there's no way to put up enough margin for perfect safety.
https://www.bloomberg.com/news/articles/2017-11-15/bitcoin-e...
So it will be interesting to see how the pricing really works.
Be prepared to put up some hefty margin, though, because shorts have a tendency to get eaten alive.
And you can still sell cryptocurrencies that you own, why exactly is shorting an asset required to value it fairly?
Does anyone argue that difficulty in short-selling residential real estate prevents it from being fairly valued?