My main objection is a philosophical one. I just don't believe that whatever is in the machine after such an "upload" will be me -- no matter how accurately is mirrors my brain.
I'll still be in my own body, and don't want to kill myself for the sake of the life of the one inside the machine. Nor do I think my life will continue inside the machine. Whatever/whoever is inside the machine at that point will no longer be me, and will continue their own life without me -- even if they think exactly like me and have exactly the memories I had at the point of upload, etc.
At best, such an upload is more akin to giving birth to a separate entity.
People who think they are extending their own lives by doing this are deluding themselves.