The only benefit I can think of that benefits is specialized software like games or scientific analysis/simulation. But for what most users want, JavaScript is fast enough. The example I keep hearing is "imagine gimp in the browser" but it's already possible to make a gimp like application in the browser using things like canvas and the file api.
So by the time webassembly is ready for the prime and has needed features like memory management and Dom access, will it even by worth it beyond a few specific applications?