There's a set of old-fashioned instruments in the cockpit - compass, altimeter, airspeed indicator, and turn-and-bank indicator that are not reliant on anything else to work.
I'm not a pilot, but if I was "in the soup" when this happens, first I'd try radioing the ATC and asking Victor for a Vector out of it. Then fly that vector straight & level. No radio, then it's old-fashioned map, compass, and dead reckoning. A 757 has a lot of range, so you should be fine.
My father was a navigator in B-17s, and used celestial navigation. I suppose they don't teach pilots that anymore.