Hacker News Reader

Comment by steadicat | Hacker News Reader

I have 23andme, but their results are not very clear. All they say is “You have two variants associated with consuming more caffeine.” I’m unsure how to square that with the studies above. Do I have fast or slow metabolism? Do I have higher or lower risk of MI?

View on HN

Looks like they revised how they present the data. Try looking in the archived reports in the drug response section. It should categorize you as a fast or slow metabolizer. You can probably figure this out also from the raw data but I can’t give you any guidance there.

https://you.23andme.com/reports/report_archive/download/repo...

Figure out what is the name of the SNP of the CYP1A2 variant, download your SNP data from 23andme and look for it yourself.

Actually I can help you out some more. The SNP in question is rs762551.

Go to Tools -> Browse RAW data -> search for rs762551.

It should show something like this:

  Gene    SNP	    genomic loc  Variants   Your result
  CYP1A2  rs762551  75041917     A or C     ? / ?

If you have A/A you're "fast metabolizer". (good) If you have A/C or C/C, you're "slow metabolizer". (not so good)

From SNPedia:

"In terms of genotypes, only rs762551(A;A) individuals are considered fast metabolizers. Individuals who are rs762551(A;C) heterozygotes or rs762551(C;C) homozygotes are both considered slow metabolizers."

Reply on news.ycombinator.com