Also compared with Coq, proofs rely heavily on SMT solving with Z3 instead of lots of manual tactics (yay!). On the other hand, where SMT solving fails, you can not resort to manual tactics because there is no tactic language. You have to write proof terms without interactive support. (This may have changed in the last few months, but I'm almost sure it hasn't.)
I wrote a bit about my experiences trying to prove things in F* two years ago: https://news.ycombinator.com/item?id=10984306
Don't rely on any of that though, things will have changed in the meantime!
I'm optimistic about F*, but at the moment you have to be quite determined to try to use it for fully verified programming. The same is true for Coq, though.