What made me realize that P?=NP is not that important for practical issues is the unbelievable effectiveness of heuristics. They seem to get extremely close to the optimum than best approximation algorithm known for the problem.
https://www.reddit.com/r/compsci/comments/78yx99/171009278_e...
For example, for travelling salesman and vehicle routing there are many instances with known optimum.
Even for those unknown tight bounds are easily achieved.