Related but different, perhaps someone with a bio/med background knows: Regarding the metformin FDA Phase 4 clinical trial for life extension and a conflicting recommendation from my PCP that metformin (1500 mg) has a significant risk of injury from acute hypoglycemia in those (like yours truly) without type-2 diabetes but being overweight (about 20%). I didn't see anything in the literature or box warnings about common hypoglycemia risks, especially in good liver & kidney functional patients, and the body can regulate glucose with a panoply of pathways. Seems to me, metformin looks like it has massive potential to benefit many people to up-regulate healthy pathways, but only if doctors understood its limitations and capabilities in settings outside of diabetes. Or am I missing or wrong about something?
https://clinicaltrials.gov/ct2/show/NCT02432287
https://www.webmd.com/drugs/2/drug-11285-7061/metformin-oral...