Qubes has a nice fat attack surface known as the hypervisor. I'm skeptical when people point to this as the panacea of computing security.
It's not a panacea. There are physical threats, there are threats from the very hardware you're using. But, like it says on the box, it is a reasonably secure operating system.
[1] https://blog.quarkslab.com/xen-exploitation-part-2-xsa-148-f...
Also, with their recent foray into enterprise support, they will hopefully be able to expand their auditing efforts in the next couple of years.