Yes, actually. Women metabolize it differently, plus size matters. Men are typically larger than women. They can handle more liquor and be less drunk. So a hetero couple that are consuming alcohol together at the same pace typically causes dramatically greater impairment for her than for him and more quickly.
Alcohol is the single most common date rape drug and is a factor in the vast majority of date rapes.
Additionally, highly sexually aroused women lose certain cognitive functions. This is not true for men. I strongly suspect this element is a significant factor in many social norms that establish different expectations for male and female sexual behavior.
Women literally have their judgment impaired by high arousal. I think this is part of why society as a whole is pickier about the need for women to pursue more cautious strategies when choosing a sex partner.