Eh. Emacs vs Vim.

2) Matlab syntax (y tho?), infix, and sigils everywhere

The target audience is scientific and mathematical users, not necessarily "programmers", and certainly not "software engineers". Matlab syntax, infix, and sygils read like math notation. The target use-case is mathematical and scientific programming. This is a benefit in my opinion.

Also, with respect to sigils, I can think of at least one popular sigil in Common Lisp: the #' reader macro for accessing functions! So much for Lisp-1 vs Lisp-2.

3) Clos and metaobject protocol and ability to adjust these as easily at run-time

Fair, but do you really need CLOS with a delightful type system and multiple dispatch?