To answer your question, no, the 747 is not "safe". No aircraft ever made is "safe". They will all crash and kill people given sufficient flight hours. The question is what we consider acceptable risk, those standards change over time as technology improves, and as regulators phase out older models by sunsetting certain exceptions.
As that's done older aircraft either need to be retrofitted, or sold to jurisdictions with laxer rules.
1. https://en.wikipedia.org/wiki/TWA_Flight_800
2. https://en.wikipedia.org/wiki/Inerting_system#Aircraft
3. https://en.wikipedia.org/wiki/Boeing_747_hull_losses#1970s