For the record, my needs in a mail client are: GUI, very clean UI, pretty themes, good search, works with gmail, ideally supports snoozing emails (a key feature if you like to pursue Inbox Zero), if at all possible should be a desktop app for OS X and Windows, and I wouldn't be adverse to open notifications and such. Also, I'm explicitly fine with their being an extra server in the mix; this is more-or-less required for snoozing emails to work properly[1], and I'm not really concerned about privacy.
If that describes you, you might like Mailspring too. If not (and I suspect that'll be the case for the median HN visitor), then probably not. :)
Edit: Totally forgot, I also have a strong need for supporting multiple email accounts. A merged inbox view that will automatically use the correct email address/signature for replying to an email based on where the original email was sent is critical.
[1]: At least, every implementation of email snoozing I've seen had relied on a third party server. And once I got addicted to it with Dropbox's much-mourned Mailbox app, I've found it very hard to use a mail client without it.