Yes, been using it as my primary development machine for the last two years. I work on a large Node / React codebase, and occasionally do design work.

My setup:

* Chromebook Pixel 2 in dev mode

* Crouton (https://github.com/dnschneid/crouton/) running CLI-only Debian stretch

* Google's SSH app (https://chrome.google.com/webstore/detail/secure-shell/pnhec...)

* Tmux running with NeoVim, cmus for music

My dotfiles and setup scripts are all here: https://github.com/fortes/dotfiles

Overall, I like this better than the old mac setup I have. Being in dev mode (and having to enter crouton chroot once per boot) aren't ideal, but I've gotten used to it. I'm hoping that maybe we'll get first class support soon though ( https://www.reddit.com/r/chromeos/comments/742f8j/how_chrome... )