For the uninitiated, how does this compare to guile?
Comes with an interpreter. Supports macros, etc. and Gambit supports easy C FFI, option for infix syntax, massive threading, full numeric tower
Easy to hack on (in my opinion), and performs very well. Gambit-C has been my "goto" Scheme for the past decade.
Could be used as an "extension language", but not its main purpose. Mostly, a way to deliver Scheme code that runs fast.
Racket has a better IDE -- but I like the simplicity of Gambit-C.