I don't know how the Hacker News community is open to those substances. But I certainly can recommend this very interesting article about psilocybin and other psychedelic drugs:
https://www.newyorker.com/magazine/2015/02/09/trip-treatment. I found the article to be very rational without being to much esoteric (which I dislike, there is too much pseudo-science in this world...)
The good news is that in the recent years, research process has never been easier with FDA and DEA. I expect the next years to be a huge leap in that domain. From what I read, it is remarkably helpful for people with terminal diseases (psilocybin helps reduce death fear). People are far more spiritual after that.
I think subconscious side of our brain is highly underrated and our society may benefits from that greater knowledge.
I know almost nothing about Ayahuasca but I guess the most important part is not the fact you took the substance but mostly the search process behind and the preparation you had.
I had a good experience with psilocybin and one thing I realized is that when the timing is right (you feel it generally), I don't have to worry about any bad symptoms (paranoia, anxiety etc).
I wish you luck but always be aware of the risks.