This to me is essentially eternal political debate between the collective vs. the individual. Do we "put down" the individual in order to promote the well-being of the collective (read tyrannical majority rule) or do we value the rights of the individual regardless of they impact the collective? I am personally on the side of the latter.
Secession is by definition a break out from the collective. So considering what the collective wants seems to me like asking the majority to vote for their tyrannical interest (very biased way of doing things).