1) Problem during launch. There's been one successful use of a launch escape system in rocketry history[1], and such a system has never been developed for a shuttle type craft.
2) Problem after entering orbit. Cutting your orbital flight short isn't going to change the fact that you still have to survive re-entry stresses and have a working vertical landing system.
[1](https://en.wikipedia.org/wiki/Launch_escape_system#Usage)