The issue of day-to-day work falling by the wayside was addressed in pg's essay on "Good and Bad Procrastination"
Hamming's Questions ("What are the most important problems in your field? Are you working on one of them? Why not?") are great, but somewhat daunting. Maybe the blow can be softened by loading those problems into ambient thought mode instead of pounding against them systematically. That was one of Feynmann's methods: keep a few hard problems in the back of your head all the time and wait to stumble on something that helps.
Still, a great series of questions to make you re-evaluate your course in life.