The "unconnected with any major publisher." part is the major one. I would say this likely doesn't affect Google and Facebook much (it might affect Facebook greatly for me, since I use the site once every couple weeks). Who it does affect is shadier third party ad networks which have less well defined privacy policies. It also affects any fully legitimate and non-shady advertiser that doesn't have a web presence you want to visit regularly. So in that respect it punishes all the non-Google and non-Facebooks equally, which may or may not be a good thing.

Google and Facebook may know too much about you, but I'm not really worried about them selling that data, which is some small relief. They are the ferryman at the river, and they charge to take advertisers to their audiences. They aren't in the business of selling boats.