Macro-Lisp, a Lisp-Like DSL for Rust Language
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did not go well
Then you'd have a lisp syntax on Rust that is not embedded. Is that correct?
You could make a build script that would read in lisp files, and then run them through a pre-processor of sorts before compiling. That's the closest thing, and it'd still require setting up that build.rs.
At that point, you would be better off using a Lisp implementation and its expander over a bunch of Lisp to Rust macros.