What is the Y100K problem.
More importantly, who would they pay out at that point when both parties are dead
Payout are to the bettor's selected charity. Or, if that's gone, the closest one we can find.
The tricky part is coming up with a clear agreement about what "cure" and "death" mean here. But there's a lot of good discussion around e.g., the extropians, so I think a solid bet could be created.
Or do you mean for your own? This is between you and the person you bet with. If you have a firm opinion, definitely find somebody on the opposite side and see if you can put together a bet.