Not just Spotify--Facebook (Business) too.
My primary browser is Chrome, but I decided I wanted to no longer be logged in on Facebook in Chrome and having my usage tracked. So I used Facebook only in Safari.
Unfortunately if you visit business.facebook.com in Safari, it tells you it's an unsupported browser. You can't set up Facebook ad campaigns or even check your business messages in Safari at all. :(
If anyone from Facebook is reading this, the iOS Facebook Pages app is also broken. Notifications of new messages to your page don't work after you put a page in Business Manager in Facebook. It's hugely frustrating.