I haven't overcome the virtual env thing. There are a few virtual environment libraries, not sure which one to use. Then it is awkward to have to change your entire environment over by activating it and for it to be global. What if I want to work on two different projects in two different terminals? Why can't I activate an environment by just CDing into a directory with my project?

Then there is the GIL. I still don't know if multithreaded python apps are really MT or just faking it. And yes, I know you can do event driven stuff and that does look very interesting.