From other parts of the country you might say things like "I took I-5" or "Interstate Five", "Route Five", "Highway Five", "US 5" etc.
"I-5" to me sounds a little harsh and hard to say to my ears vs. "I-95" or "I-80" which have a nicer ring to them, so maybe that's how this sort of thing could develop if that's just how the major highways ended up being numbered in different parts of the country.