If your threat model includes being abducted and drugged, basically nothing will save you.
No, eyes need to be open, the user has to be "paying attention".
If someone is willing to do that to you, odds are that they're also willing to apply a crowbar to your limbs should you fail to comply with unlocking the phone.
There is far worse they could do to you in that state that open your iPhone...
Biometric has the same issues regardless of touch or facial recognition.