So, there are two main areas of development in the automation of theorem proving.
The first one is proof assistants, such as Isabelle/HOL, HOL Light, HOL4, Coq, PVS, Lean, TLApm (and others). These are typically languages to be used directly by a human, and share many common features with programming languages. In a sense, you "program" your proof. There are some large developments in such languages, as pointed out in other comments, including the Kepler conjecture (in HOL Light), the 4 colors theorem and Feit-Thompson theorem (in Coq), a fully verified micro-kernel (SEL4, in Isabelle/HOL), etc. It's an active research area with multiple teams around the world, but the provers are still difficult to use for non-experts. Isabelle/HOL has some nice features and good documentation that make it a bit more approachable to newcomers, afaik, and Lean has promising design decisions, but clearly right now it's a lot of effort to formalize anything consequent in proof assistants.
The second area is fully automatic provers — an endeavour started very early (50s, 60s?). Such provers accept a logic formula as input, and try to compute if it's a theorem or not. They typically accept more restricted fragments of logic (because it's a super hard problem!). Even first-order logic, which is less expressive (and convenient) than the higher-order logic usual in proof assistants, is semi-decidable only because of Gödel's incompleteness theorem. This means a prover for this logic will never terminate on some inputs that are not theorems. There still are interesting provers for FOL, e.g. [E](https://eprover.org). More restricted fragments that tools can effectively deal with are SAT (purely propositional logic, solvers are very good nowadays) and SMT (SAT + theories such as arithmetic) which is very useful in software verification (e.g. liquid haskell's type system, why3, boogie, F*, etc.).
There are people trying to join both domains of research by developing so-called "hammers", that make automatic provers available in proof assistants to make small proof steps entirely automatic.