It is common to want to ask a database "tell me all groups of size greater than X, with properties A, B and C". Now, if you have arbitrary sized ints, no problem. If your database (or language) doesn't support big ints, you need to figure out how to do "bigger than X", when you are storing big numbers in some other format, probably strings.
If you can sort a numeric string in base 10, you can sort one in base 16, or base 64, or base 256.
However, the important bit (to me) is that you can use your database's sorting function to compare the numbers.
The advantage of base-10 is it's easy to display the number :) Others bases do provide a constant speed improvement of course.
In fact I'd make an index on (len(N), N), then include len(X) and X in all your comparisons and range queries (wrapping for ergonomics as needed). You can use any base storage (including compact varbinary base256).