Ive had severe wrist pain before, saw occupational therapists, was diagnosed with repetitive stress disorder, changed hands for the mice, tried trackballs, trackpads, ergonomic mice, the only thing that worked for me was getting a Wacom tablet. It turned out that it was clicking the mouse button that aggravated my wrist. Been pain free for years except when I play too much with my phone. It takes about a week to get used to the tablet but I actually prefer it to the mouse now, even when not taking into account the wrist pain. Good luck.