Grew up in Appalachia. I agree with some of the points made by Vance in Hillbilly Elegy. I don't think he has a lot of details right, and he's not from Appalachia himself.
However, he's not wrong on cultural dysfunction.
I should also point out that Hillbilly Elegy has been embraced by the same political class that rejected the same key points made by Charles Murray here:
http://www.nytimes.com/2012/02/12/books/review/charles-murra...
I should also note that Vance's book could only have succeeded as a critique of working-class white culture. Had a black man written a book like this about cultural dysfunction in his own community, he'd be vilified and marginalized as an "Uncle Tom" blaming the victims.