- Slow iteration, each mistake that you could learn from potentially costs a hundred lives
- No graceful shutdown possible most of the time – if automation fails in a car, you just stop or pull over, you probably won't die. A plane can't just land itself if automation fails unless the comm link works
- Comm link might not always work, it can be damaged from light mid air collisions, bird strikes, drone strikes, other damage, improper maintenance, possibly bad weather, hacking, jamming, over-saturation due to mass automation failures etc.
To me it seems that it's easier to deal with road chaos than acquire an extra couple 9s of uptime in this problem.