I've used both on Fedora, and found tuned to be easier-to-use and more effective. tlp also does not work well with SELinux, and as such causes a flurry of errors every time you change the power state (sleep, resume, plug, unplug), which may be part of why I found it ineffective.

The way I set up my tuned profile is pretty simple:

    sudo dnf install tuned-utils
    sudo powertop2tuned -n laptop

Then, I edited the profile in `/etc/tuned/laptop/tuned.conf` and enabled things. On my Thinkpad X220, simply enabling everything worked great, but my Asus ROG laptop and my friend's Razer Blade had issues with that, so YMMV wrt what to enable. Then, I added USB autosuspend support by adding the following to the profile:

    [usb]
    autosuspend = 1

After that, I ran `sudo tuned-adm profile laptop`, which sets it and tells tuned to start on boot, and have had vastly improved battery life, good performance, and no hassles since.