I concur on this. In my phd thesis, I defined macros for all frequently used mathematical terms and expressions. This way, many places got almost as readable as the rendered formula.
For example, "\tfuzzy(1,2,3)", denoting a triangular fuzzy number with min. support 1, modal value 2 and max. support 3, is pretty clear after using it once or twice. We can then decide later how exactly to render it by changing the macro definition.
Similarly, when citing a lot of names (just using the names here, not actually paper references) wich characters which are not in my commonly used alphabet, I frequently define macros for them too. Then I can use e.g. "\Mares" in the text instead of "Mare{\v{s}}". Much easier, also when compared to hunting those special chars in a character map in a WYSIWYG word processor, or copy-pasting all the time.
However, I find this use of macros really only really pays off when working on larger documents, or living documents that keep changing, like CVs. For shorter and short-lived docs, I'd use Latex only if they have at least some math or special layouting requirements. I tried using Word's formula editor, but even though one can sort of get used to it, I find Latex much easier to use, especially with amstex. But for shorter documents without math, I find a word processor just much more convenient.
I'd also be surprised if word's implementation was anywhere near as powerful as a full-on search replace on latex using regexps.
In Microsoft Word for Windows it's the "Styles" bar, and on MacOS it's the "Styles Pane".
It would be interesting to see a word processor that enforced style usage...
And sure, it takes some discipline to use styles, but that goes for any other option as well (apart from things like Docbook maybe). You're supposed to use \em in LaTeX instead of \textit for the same reasons you're supposed to use an Emphasis style in Word instead of italic text. The only difference is that the mechanism is the same in LaTeX (type a few characters – which is pretty much why for any given macro you'd be hard-pressed to actually decide whether it's semantic or presentational), while in Word it's a separate feature.