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Comment by Madmallard | Hacker News Reader

It's mitochondrial dysfunction

Fairly obvious if you look enough at the research

mitochondrial disease patients rarely get diagnosed as adults and they often suffer a lot of complications unnecessarily as a result

Our medical system is awful at dealing with it - chronic stress and anxiety are certainly related to metabolic disturbances as well according to research so that makes it an easy target for doctors to "explain away".

also antibiotics cause mitochondrial dysfunction (particularly bacteriocidal antibiotics)

chronic stress and sleep deprivation "raise your susceptibilty" to chronic fatigue and fibromyalgia - yeah becuase they lead to excess oxidative stress

CFS patients are probably surgery risks as well then since propofol and the like inhibit mitochondria

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> antibiotics cause mitochondrial dysfunction (particularly bacteriocidal antibiotics)

You are very assertive, but this proves that you don't know what you are talking about. Antibiotics are all "bacteriocidal".

Beside, saying the mitochondries are responsible is like saying that the arm is responsible of an incapacity to move an arm. It could be due to a neurological, muscular or squeletical root cause. Mitochondries are the factories of ATP but there are many other factors in play.

A cause could be a lack of oxygen due to nocturnal apnea, etc. Lack of vitamins, lack of iron and/or red cells, etc. etc.

I happen to share your skepticism about a mitochondrial origin for this syndrome, though I am not familiar with the research (would appreciate a review on the topic - I saw one linked earlier in the comments from BMC Genetics that seemed to conclude that mitochondria are not involved).

> You are very assertive, but this proves that you don't know what you are talking about. Antibiotics are all "bacteriocidal".

I also found this confusing when I first learned about it, but some antibiotics work by directly killing organisms (i.e., are bacteriocidal) whereas others simply block the ability of bacteria to grow (i.e., are bacteriostatic). [1]

There are a few clinical cases where one would avoid bacteriocidal antibiotics, as the internal contents of a bacterium could further worsen a patient's symptoms.

1. By no means an authoritative reference, just a cool demonstration of this concept: https://www.ncbi.nlm.nih.gov/pubmed/24284484

Certainly a possibility - but stress on mitochondria is almost inevitable whatever the cause, so the question remains as to whether this is upstream or downstream in the chain of causation, or a necessary but not sufficient condition that might not be the cause.

>Our medical system...

Yeah, an anecdote. The USA spend through the federal (only!) budget roughly $4 000 B every year, yet they don't fund properly even people like Dr. Todd Rider. The man asked just for $2 M for his DRACO research (100% effective proved cure against viruses like flu, herpes, etc) - it's like to ask for two coins from a stack 4 km long. Two coins and four kilometers stack of those. Every effing year!

And do you know how they treated Dr. Tullio Simoncini? This society is fawked, hahahah.

> The man asked just for $2 M for his DRACO research (100% effective proved cure against viruses like flu, herpes, etc)

Why would you still be researching if it's 100% proven? Maybe the claim that it's proven is a lie?...

Yeah, I need to clarify. Proven by in vitro only experiments:

https://www.indiegogo.com/projects/dracos-may-be-effective-a...

https://www.bloomberg.com/news/articles/2011-11-03/todd-ride...

https://riderinstitute.org/

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