F5 | Up | F2
Left | Down | Right
Tab | Delete| Backspace
Enter | Space | ESC
How many times an hour do you have to reach over to the keyboard, press an arrow or Enter, then have to reach over and find your mouse again? All those seconds add up! Do your eyes leave the screen to find your mouse? This configuration lets you maintain your state of flow, because your hand almost never leaves your mouse, except for actual typing.You'd be surpised how many tasks can be performed with just the mouse (and the left hand for CTRL+C,CTRL+V). This is the most efficient layout I've found. I've used this for about 5 years now, for massive performance gains in many administration and development roles.