Is there support is OS X for changing normal letter keys into properly functioning modifier keys?
CMD with my thumbs, and Shift, are the only modifiers I can comfortably type. RSI pain in my pinkies really limits Option and Ctrl.
It would be interesting to have a chording setup with keys on the home row. Hold "D" + type a key with your Right hand, and vice versa for "K" and the Left hand.