In theory, one could make an amoeba play piano somehow, if we think of a piano broadly speaking as just an array of notes with various associated variables (pitch, force, etc).
I'm thinking... using chemical signals of some sort to force amoeboid cells to move in certain directions or take certain shapes, we can control gradiants of amoeba in sequence, and thus "teach" them encoded piano music.
But I'm not sure how this applies to AI.