So, yes a MIV could take out 8-10 cities across Texas while not impacting 99% of the land. But, a more likely approach is to carpet bomb suberbs and redundantly target cities with different warheads from different ICBMs.
Thus, 1000 MIRVs would not get 1000x the dammage as single areas would be targeted multiple times and of course targets get harder to pick. Central West Virginia for example due to all those mountains and minimal population would take a lot of nukes or largely get left alone.