What's going to be the next "really big" thing?

I don't know about "next", but I can't wait for extremely intelligent personal software agents. I don't have the time to browse dozens of RSS feeds, check Facebook and other networks. An agent that can browse everything I'm connected to, learn what's really important to me and then only give me the digest would be wonderful.

Going further, I want to be able to say to it: "hmmm I should get to the dentist before I catch a movie with Brian on Tuesday" and let it and my dentist's agent and Brian's agent negotiate the appointments.

A personal assistant for everyone.

Not anything internet related.

Personal robotics. Fully autonomous robots, cars, trucks, planes that can operate in the personal domain (cities, houses, roads) not just factory floors. No guide wires, etc. Autonomous agents that can pick up pizza, drive me across country, do any task. The app store will be for task enabling. It's 10-20 years off, but will lead to massive, widespread, disruptive, innovation.

Somebody needs to sort out liability issues so technologists can get to work.

Cloud computing...