I've been using do not disturb mode and airplane mode daily in the evening until early morning. It makes for a great break from the constant barrage of notifications.
Yes I miss a few calls, but there's rarely anything that can't be followed up with (I put my phone on vibrate if I'm expecting an important call), and the peace of mind it brings (and reduced flow interruption) has been fantastic.
I just can't make them spell out what they want; it has to be the phone...
I guess if you get a lot of those each day it might be a problem for me I might get a single message or two each day.
I also allow notifications from a single email address but that's because it gets errors and not much else sent to it.
Everything else can be handled when I feel like it.