The timing of this video is a lesson in humility. It's posted one month before a positive earnings report showing high growth in active buyers that gives the stock an ongoing 1.3x price increase. As far as I have viewed, Shkreli seems ambivalent, using vague heuristics to predict the future -- expectation of a yahoo-like slow decline, poor UX and discovery, and stiff Amazon competition.
https://www.google.com/finance?q=NASDAQ:EBAY (click 5y)
https://www.fool.com/investing/2016/08/11/why-shares-of-ebay...