Clojure default of immutable hash maps and vectors was really bold. They had to innovate by giving a twist to Bagwell's great research on data-structures, and they managed to build what in my opinion are the first set of general data-structures suitable of representing traditional hierarchical object-tree data-models immutably, at the scale of large interactive software.
Without these, the single-atom architecture that now is popular as ever with Redux, Elm, etc. would not be possible. The flourishing of functional programming for interactive software that followed shows to me that the biggest impediment before was not the lack of functional ways of expressing interactions (the Haskell people have devoted a lot of notable effort in the FRP camp). Instead, just having efficient data-structures to write persistent document models, escaping the rigidity of lists and rb-trees, allows you to write big interactive sofware in a functional manner even with the most dumb abstractions (which is a good thing, KISS!) and even stupid language (JavaScript!).
This has inspired me to work on a generic implementation in C++, which also has experimental Python and Guile bindings: https://sinusoid.es/immer/ https://github.com/arximboldi/immer/
In the past I also did some other work on bringing Clojure Transducers to C++ (https://www.youtube.com/watch?v=vohGJjGxtJQ&t=1614s) but I know consider it a much less important effort---without the data-structures the other parts of Clojure feel almost like just sugar.
EDIT1 -- Sorry for the shameless plug ;)
EDIT2 -- Grammar